Diadenosine Pentaphosphate Pentasodium Salt

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£292.00

SKU:: 296060
Molecular Weight:: 1026.28
Purity:: ≥95% (HPLC)
Storage Conditions:: -20°C
Supplier:: United States Biological
CAS Number:: 4097-04-5
Format:: White to off-white powder
Extra Details:: Diadenosine pentaphosphate pentaammonium is an endogenous vasoactive purine dinucleotide which has been isolated from thrombocytes. Diadenosine polyphosphates (ApnA, n=2–7) have been identified as constituents of secretory vesicles such as in platelets, chromaffin cells, Torpedo synaptic terminals and brain synaptosomes. P1,P5-Di(adenosine-5′) pentaphosphate (Ap5A) is a diadenosine polyphosphate, which has a tail-to-tail dimer structure. Ap5A is synthesized in a twostep process involving the formation of adenosine 5′-tetraphosphate (P4A) from the ATP and trimeta-phosphate (P3). In the second step, P4A is converted to Ap5A. The synthesis of Ap5A requires a pH optimum in the range of 7.5 to 8.5 and is modulated by metal ions. Applications: • an adenylate kinase (AK) inhibitor in: sarcoma osteogenic (Saos-2) cells • mitochondrial lysates during ATP synthesis • tetramethylrhodamine methyl ester (TMRM) based membrane potential assay • chromoplasts Synonyms: P1,P5-Di(adenosine-5') pentaphosphate pentasodium salt; A(5′)P5(5′)A, Diadenosine pentaphosphate pentasodium salt CAS Number: 4097-04-5 Molecular Formula: C20H29N10O22P5·5Na Molecular Weight: 1026.28 Purity: ≥95% (HPLC) Appearance: White to off-white powder Solubility: Water: 50mg/ml Storage and Stability: Store at -20°C under inert atmosphere. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

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