4-Deoxyuridine (Zebularine)

Size

£288.00

SKU:: 295906
Molecular Weight:: 228.21
Storage Conditions:: 4°C
Supplier:: United States Biological
CAS Number:: 3690-10-6
Extra Details:: A cytidine analogue and inhibitor of DNA methyl transferases (DNMTs) with anti-cancer activity. This stable, hydrophilic compound forms covalent complexes between DNMT and zebularine-substrate DNA. It causes DNA lesions that block replication and cause replication fork collapse, leading to the formation of DNA double-strand breaks. It was also shown that zebularine-induced DNA methylation decrease in the IL-1β promoter region and disrupts molecular mechanisms of neuroinflammation. Moreover, this molecule down-regulates the DNA-methylation profile in the pluripotency genes’ promoters, which leads to improved development of somatic cell nuclear transfer (SCNT) embryos. Synonyms: 1-β-D-Ribofuranosyl-2(1H)-pyrimidinone; 4-Deoxyuridine; NSC 309132; Pyrimidin-2-one β-D-Ribofuranoside; Zebularine CAS No: 3690-10-6 Molecular Formula: C₉H₁₂N₂O₅ Molecular Weight: 228.21 Purity: ≥98% Appearance: White to off-white powder 1H NMR: Conforms to reference Melting Point: >150˚C (dec.) Solubility: DMSO (Slightly), Methanol (Slightly), Water (100mM) Storage and Stability: Store at 4°C. Hygroscopic, under inert atmosphere. For maximum recovery of product, centrifuge the original vial prior to removing the cap.