UDP-D-Glucuronide Ammonium Salt

Size

£798.00

SKU:: 295071
Molecular Weight:: 580.29
Purity:: ≥98%
Storage Conditions:: -20°C
Supplier:: United States Biological
CAS Number:: 43195-60-4
Format:: White to off-white powder
Extra Details:: UDP-D-glucuronide ammonium salt is a drug that is used for the treatment of estrogen-dependent cancers. It is an inhibitor of human UDP-glucuronosyltransferase, an enzyme that catalyzes the glucuronidation of estrone and other substrates. The binding affinity of UDP-D-glucuronide ammonium salt can be increased by mutating the enzyme to increase its kinetic rate. This drug has been shown to inhibit estrogen production in recombinant human liver cells as well as in human liver cells. Mutations in the gene encoding this enzyme have also been associated with variations in estrogen levels, specifically high rates. Synonyms: UDP-GlcA; UDPGA, Uridine-diphosphate-glucuronic acid ammonium salt; Uridine[5′]diphospho[1]-α-D-glucopyranosuronic acid CAS No: 43195-60-4 Molecular Formula: C15H22N2O18P2·xNH3 Molecular Weight: 580.29 (free acid) Appearance: White to off-white powder Purity: ≥98% Water (KF): ≤10% Phosphorus (Dry basis): 9-11% Ammonia (Dry basis): 1-10% Solubility: Water, 50mg/ml Storage and Stability: May be stored at RT for short-term only. Long-term storage is recommended at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.