286999
Pranlukast
Size
£256.00
- SKU:
- 286999
- Molecular Weight:
- 481.5
- Purity:
- ≥98%
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- CAS Number:
- 103177-37-3
- Format:
- Supplied as a crystalline solid
- Extra Details:
- Cysteinyl leukotriene receptor antagonist. The cysteinyl leukotrienes (CysLTs) LTC4 and LTD4 are potent mediators of asthma and hypersensitivity. They induce bronchoconstriction, increase microvascular permeability, and are vasoconstrictors of coronary arteries. Their biological effects are transduced by a pair of G protein-coupled receptors, CysLT1 and CysLT2.1,2,3 Pranlukast (ONO-1078) is a potent, selective and orally active cysteinyl leukotriene1 (CysLT1) receptor antagonist.4 Sold under the trade name Ultair, it was the first cysteinyl (peptidyl) leukotriene receptor antagonist (LTRA) marketed for the treatment of asthma.5 Clinical studies in Japan, Europe, and North America all show that pranlukast significantly attenuates bronchoconstriction in response to a variety of allergen challenges as well as to inhaled LTD4.5 Pranlukast binds to the human CysLT1 and CysLT2 receptors with IC50 values of approximately 4-7nM and 3,600nM, respectively. Synonyms: N-{4-Oxo-2-(1H-tetrazol-5-yl)-4H-1-benzopyran-8-yl]-4-(4-phenylbutoxy)benzamide; ONO-1078; ONO-RS-411; Onon; Ultair CAS Number: 103177-37-3 Molecular Formula: C₂₇H₂₃N₅O₄ Molecular Weight: 481.50 Purity: ≥98% Appearance: White to off-white crystalline powder Melting Point: 236-238°C (lit) Solubility: Soluble in DMSO at 10mg/ml and DMF at 20mg/ml. Storage and Stability: May be stored at -20°C. Stable for 6 months after receipt at -20°C. Reconstitute with sterile buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
- Shipping Conditions:
- Blue Ice