DL-4-Hydroxy-2-Ketoglutarate Lithium Salt

Size

£448.00

SKU:: 279270
Molecular Weight:: 162.1
Purity:: ≥90% (TLC)
Storage Conditions:: -20°C
Supplier:: United States Biological
CAS Number:: 1187-99-1
Format:: White to off-white powder
Extra Details:: DL-4-Hydroxy-2-ketoglutarate dilithium salt (DL4KG) is a lysine analogue that is used as a substrate for the enzyme aldolase. DL4KG has a hydroxyl group, which can react with the amino group of lysine residues on proteins to produce an unstable intermediate. This process eventually leads to the production of glutamate and glyceraldehyde 3-phosphate, which are needed in the synthesis of ATP. DL4KG has been shown to be an inhibitor of bacterial enzymes such as glutamate dehydrogenase, which catalyzes the conversion of L-glutamic acid to L-glutamine. Inhibition by DL4KG has been demonstrated in vitro at concentrations between 2-10mM. Synonyms: 4-Hydroxy-2-oxoglutaric acid lithium salt; DL-KHG Li CAS No: 1187-99-1 Free Acid: 162.10 Molecular Formula: C5H6O6·xLi+ Molecular Weight: 162.10 Free Acid Purity: ≥90% (TLC) Appearance: White to off-white powder Water: ≤15% Method of Determining Identity: Proton NMR Spectometry Lithium (anhydrous basis): 3.9-8.4% Storage and Stability: May be stored at RT for short-term only. Long-term storage is recommended at -20°C. Bottomless glass bottle. Contents are inside inserted fused cone. For maximum recovery of product, centrifuge the original vial prior to removing the cap.