1-Amino-2-naphthol-6-sulfonic Acid

Size

£400.00

SKU:: 260397
Molecular Weight:: 239.25
Purity:: ≥95%
Storage Conditions:: 4°C
Supplier:: United States Biological
CAS Number:: 5639-34-9
Format:: White to light brown powder
Extra Details:: 1-Amino-2-naphthol-6-sulfonic acid (ANSA) is a sulfonic acid that has been shown to inhibit the activity of the sodium/potassium ATPase pump. ANSA is excreted in the urine and faeces, and has been detected in human secretomes. This drug binds to the enzyme binding site on the pump, inhibiting its function and leading to inhibition of cellular uptake of sodium ions. ANSA has also been shown to be active against cancer cells in vitro. It binds to DNA and inhibits DNA synthesis by inhibiting RNA transcription. The drug also inhibits protein synthesis, which may be mediated by its ability to inhibit ribonucleotide reductase activity. Further toxicological studies are needed as this drug is not currently approved for medical use in humans. Synonyms: 1-Amino-2-hydroxynaphthalene-6-sulfonic acid; 5-Amino-6-hydroxy-2-naphthalenesulfonic acid; 2-Naphthalenesulfonic acid, 5-amino-6-hydroxy- CAS No: 5639-34-9 Molecular Formula: C10H9NO4S Molecular Weight: 239.25 Appearance: White to light brown powder Purity: ≥95% Storage and Stability: May be stored at RT for short-term only. Long-term storage is recommended at 4°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.