(R)-3-Amino-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4 ,3-α]pyrazin-7(8H)-yl)-4-(2,4,5- trifluorophenyl)butan-1-one phosphate anhydrous

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£314.00

SKU:: 258448
Molecular Weight:: 505.31
Storage Conditions:: 4°C
Supplier:: United States Biological
CAS Number:: 654671-77-9, 654671-78-0
Extra Details:: (R)-3-Amino-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4 ,3-α]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one phosphate anhydrous (TZP) is a drug candidate for the treatment of diabetes. TZP is a prodrug that is metabolized by the liver and gut to the active compound sitagliptin phosphate (SGP). TZP has been shown to reduce plasma glucose levels in diabetic rats. In vitro experiments have shown that TZP inhibits dipeptidyl peptidase IV (DPP-IV), which is an enzyme that degrades incretins such as glucagon like peptide 1 and glucose dependent insulinotropic polypeptide. Synonyms: Sitagliptin phosphate anhydrous CAS Number: 654671-78-0 Molecular Formula: C16H15F6N5O•H3O4P Molecular Weight: 505.31 Melting Point: 203°C Identity by NMR: Conforms to structure Appearance: Supplied as a white to off-white powder Purity (HPLC): ≥98% Storage and Stability: Store at -20°C under inert atmosphere. For maximum recovery of product, centrifuge the original vial prior to removing the cap.