MKT 077

Size

£351.00

SKU:: 255838
Molecular Weight:: 441.01
Purity:: ≥98% (HPLC)
Storage Conditions:: 4°C
Supplier:: United States Biological
CAS Number:: 147366-41-4
Format:: Orange-red solid
Extra Details:: MKT-077 is used in the treatment of Alzheimer’s diseases and other tauopathie’s. Also, is a rhodacyanine derivative that selectively targets cancer cells and overcomes tamoxifen resistance. Binds mot-2; selectively cytotoxic in cancer cells. Biological Activity: Occupies mortalin-2 (mot-2), a member of the Hsp70 family, at its p53 binding site and enables p53 translocation to the nucleus. Selectively cytotoxic; causes growth arrest of cancer cells in culture. Also inhibits telomerase activity and cross-links F-actin. Synonyms: 1-Ethyl-2-[[3-ethyl-5-(3-methyl-2(3H)-benzothiazolylidene)-4-oxo-2-thiazolidinylidene]methyl]-pyridinium Chloride; FJ 776 CAS No: 147366-41-4 Molecular Formula: C₂₁H₂₂N₃OS₂⁺ • Ci Molecular Weight: 441.01 Appearance: Orange-red solid Purity: ≥98% 1H NMR: Consistent with structure Mass Spectrum: Consistent with structure Microanalysis: Carbon Hydrogen Nitrogen Theoretical 57.19 5.26 9.53 Found 56.93 5.31 9.44 Solubility: Soluble to 50mM in water and to 50mM in DMSO Storage and Stability: Store at 4°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.