255773
ME 0328
Size
£421.00
- SKU:
- 255773
- Molecular Weight:
- 321.37
- Purity:
- ≥98% (HPLC)
- Storage Conditions:
- 4°C
- Supplier:
- United States Biological
- CAS Number:
- 1445251-22-8
- Format:
- White solid
- Extra Details:
- Inhibitor of PARP-3 (IC50 = 0.89 μM). Displays selectivity for PARP-3 over PARP-1, PARP-2 and other ARDT enzymes (IC50 values are 6.3, 10.8 and >30 μM respectively). Enhances CRISPR-Cas9-mediated HER2 mutation frequency, resulting in increased reduction in proliferation of HER2-positive breast cancer cells. Cell permeable. Synonyms: 3,4-Dihydro-4-oxo-N-[(1S)-1-phenylethyl]-2-quinazolinepropanamide CAS No: 1445251-22-8 Molecular Formula: C₁₉H₁₉N₃O₂ Molecular Weight: 321.37 Appearance: White solid Purity: ≥98% (HPLC) TLC Rf = 0.6 (Chloroform:Methanol [9:1]) 1H NMR: Consistent with structure Mass Spectrum: Consistent with structure Optical Rotation [α]D: -37.8 (Concentration = 0.65, Solvent = DMSO) Microanalysis: Carbon Hydrogen Nitrogen Theoretical 71.01 5.96 13.08 Found 70.83 5.94 13.03 Solubility: DMSO to 100 mM Storage: 4°C
- Shipping Conditions:
- Blue Ice