J 104129 Fumarate

Size

£576.00

SKU:: 255545
Molecular Weight:: 500.63
Storage Conditions:: 4°C
Supplier:: United States Biological
CAS Number:: 257603-40-0
Extra Details:: Potent M3 muscarinic receptor antagonist that displays ~ 120-fold selectivity over M2 receptors (Ki values are 4.2, 19 and 490nM for human M3, M1 and M2 receptors respectively). Exhibits >250-fold bronchial selectivity; inhibits ACh-induced bronchoconstriction but not ACh-induced bradycardia (KB values are 3.3 and 170 nM for rat trachea M3 and rat right atria M2 receptors respectively). Synonyms: (αR)-α-Cyclopentyl-α-hydroxy-N-[1-(4-methyl-3-pentenyl)-4-piperidinyl]benzeneacetamide Fumarate; (αR)-α-Cyclopentyl-α-hydroxy-N-[1-(4-methyl-3-pentenyl)-4-piperidinyl]benzeneacetamide (2E)-2-Butenedioate (1:1) (salt) (9CI) CAS Number: 257603-40-0 Free Base: 244277-89-2 Molecular Formula: C₂₄H₃₆N₂O₂ • (C₄H₄O₄) Molecular Weight: 500.63 Purity: ≥99% (HPLC) Appearance: White solid Solubility: DMSO to 100mM, ethanol to 50mM Method for Determining Identity: Proton NMR Spectroscopic and Mass Spectrometric analysis TLC Conditions: Rf=0.52 (Dichloromethane: Methanol: Ammonia soln [9:1:0.05]) Microanalysis: Calculated: %C: 67.18, %H: 8.05, %N: 5.60 Optical Rotation: [a] = -7.7 (Concentration=1, Solvent=Methanol) Storage and Stability: Powder is stable for 6 months after receipt at 4°C.