Erastin

Size

£307.00

SKU:: 255262
Molecular Weight:: 547.04
Purity:: ≥98%
Storage Conditions:: 4°C
Supplier:: United States Biological
CAS Number:: 571203-78-6
Format:: Supplied as a white solid
Extra Details:: Erastin is a selective antitumor agent that displays greater lethality in human tumor cells harboring mutations in the oncogenes HRAS, KRAS or BRAF. It binds to mitochondrial volatage-dependent anion channels (VDAC) proteins, more specifically on VDAC2 and alters its gating. Erastin rapidly induces an oxidative, non-apoptotic cell death in several human tumors harboring activating mutations in the RAS-RAF-MEK signaling. Synonyms: 2-[1-[4-[2-(4-Chlorophenoxy)acetyl]-1-piperazinyl]ethyl]-3-(2-ethoxyphenyl)-4(3H)-Quinazolinone CAS No: 571203-78-6 Molecular Formula: C₃₀H₃₁ClN₄O₄ Molecular Weight: 547.04 Appearance: Supplied as a white solid Purity: ≥98% Melting Point: 173-177ºC Solubility: Chloroform (Slightly), DMSO (Slightly, Heated), Methanol (Slightly) Method for Determing Identity: Proton NMR (DMSO-d6, CDCl3) and Mass Spectrometric Analysis TLC Conditions: SiO2; Ethyl Acetate: Hexane=9:1; Visualized with UV and AMCS; Single Spot, Rf=0.55 Elemental Analysis: Calculated: %C: 65.87; %H: 5.71; %N: 10.24 Storage and Stability: May be stored at RT for short-term only. Long-term storage is recommended at 4ºC. For maximum recovery of product, centrifuge the original vial prior to removing the cap.