PDE9A (cGMP specific 3' 5' cyclic phosphodiesterase Type 9, CGMP-specific 3'5'-cyclic phosphodiesteraseType 9, High-affinity cGMP-specific 3'5'-cyclic phosphodiesterase 9A, HSPDE9A2, PDE 9A, Phosphodiesterase 9A) (Not for Export EU)

Size

£731.00

SKU:: 254233
Purity:: Serum
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Rabbit
Immunogen:: Synthetic peptide, corresponding to amino acids at the C-terminal of Human PDE9A
Format:: Supplied as a liquid.
Extra Details:: Phosphodiesterase 9A is a cGMP-specific phosphodiesterase. PDE9A activity is inhibited by zaprinast, but it is insensitive to rolipram, vinpocetine, SKF-94120, dipyridamole, and IBMX. More than 20 alternatively spliced variants have been reported (Rentero et al. 2003). PDE9A has been implicated in penile erectile dysfunction, as well as in functional disturbances in which intraneuronal signal transmission via second messengers are important in the pathophysiology (example, bipolar affective disorder). PDE9A is the only cGMP-specific PDE with significant expression in the forebrain, and as such is likely to function in NO-cGMP signaling. Applications: Suitable for use in Western Blot, Immunoprecipitation, Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 1:2000-1:5000. Predicted molecular weight: 68kD Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.