PDE11A (cAMP and cGMP cyclic nucleotide phosphodiesterase 11A, cAMP and cGMP phosphodiesterase 11A, cAMP phosphodiesterase 11A, cGMP phosphodiesterase 11A, Cyclic nucleotidephosphodiesterase 11A, Cyclic nucleotide phosphodiesterase 11A1, Dual 3' 5' cyclic AMP and GMPphosphodiesterase 11A, FLJ23693, MGC133355, MGC133356, PDE 11A, PDE11A, PDE11A1, Phosphodiesterase 11A) (Not for Export EU)

Size

£731.00

SKU:: 254225
Purity:: Serum
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Rabbit
Immunogen:: Designed from the C-terminal region common to all known 11A isoforms
Format:: Supplied as a liquid.
Extra Details:: The PDE11A gene encodes for a dual-specificity Phosphodiesterase (PDE), which is expressed in the adrenal cortex and is partially inhibited by tadalafil and other PDE inhibitors. PDEs are known to catalyze cAMP and cGMP to 5'-AMP and 5'GMP, respectively and thereby regulate the intracellular concentration of these nucleotides. Loss-of-function mutation of the PDE11A gene is shown to increase cAMP signaling and cAMP-responsive element binding protein (CREB) phosphorylation, two conditions which are associated with adrenocortical hyperplasia, adenomas, and Cushing syndrome. Applications: Suitable for use in Western Blot, Immunoprecipitation, Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 1:5000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.