OVCA1 (Candidate Tumor Suppressor in ovarian cancer 1, Diphthamide biosynthesis Protein 1, Diphthamide biosynthesis Protein 2 Homolog like 1, Diphthamide biosynthesis Protein 2 like, Diptheria toxin resistance Protein required for diphthamide biosynthesis (Saccharomyces) like 1, Diptheria toxin resistance Protein required for diphthamide biosynthesis like 1, DPH like 1 (S.cerevisiae), DPH like 1, DPH1, DPH1 Homolog (S. cerevisiae), DPH1 Homolog, DPH2 like 1, DPH2L, DPH2L1, FLJ33211, HsDph1, Ovariancancer Associated gene 1, Ovarian cancer Associated gene 1 Protein, Ovarian Tumor Suppressorcandidate 1) (Not for Export EU)

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£731.00

SKU:: 254207
Application:: WB
Purity:: Serum
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Rabbit
Immunogen:: Synthetic peptide: RGRISRGRLANQ conjugated to KLH, corresponding to aa20-31 of Human OVCA1
Format:: Supplied as a liquid in PBS, 0.09% sodium azide.
Extra Details:: Chromosome 17 is a hotspot for chromosomal aberrations in breast and ovarian cancer. Candidate oncogenes and tumor suppressors located on this chromosome include OVCA1 and OVCA2, p53, BRCA1, HER2/neu and others. OVCA1 and 2 map to a highly conserved region on human chromosome 17p13.3 that is deleted in 80% of ovarian cancers and shows frequent loss of heterozygosity in breast cancers . OVCA1 is induced by BRCA1 and is closely linked to p53, a well-known tumor suppressor gene. The close linkage of OVCA1 and p53 suggests that coordinated loss of the two genes may lead to ovarian, breast and other tumor types. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1:1000. Predicted molecular weight: 48kD Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.