ORC6L (ORC 6, ORC6, Origin recognition Complex Subunit 6, origin recognition ComplexSubunit 6 Homolog like (yeast), origin recognition Complex Subunit 6 Homolog like 2, originrecognition Complex Subunit 6 like (yeast))

Size

£563.00

SKU:: 254206
Purity:: Purified by Protein G affinity chromatography.
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Rat
Immunogen:: Full length protein (Human): ORC6L
Clone:: 3A4
Format:: Supplied as a liquid in PBS, 0.09% sodium azide.
Extra Details:: The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. ORC6L is a subunit of the ORC complex. It has been shown that ORC6L and and ORC1L are loosely associated with the core complex consisting of ORC2L 3L 4L and 5L. Gene silencing studies with small interfering RNA demonstrated that ORC6L plays an essential role in coordinating chromosome replication and segregation with cytokinesis. Applications: Suitable for use in Western Blot, Immunoprecipitation, ChIP. Other applications not tested. Recommended Dilution: Western Blot: Use at 1:1000. Predicted molecular weight: 28kD Optimal dilutions to be determined by the researcher. Hybridoma: P3X63-Ag8.653 myeloma cells with spleen cells from Balb/c mice. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Shipping Conditions:: Blue Ice