Fbxw7/Cdc4 (AGO, Archipelago Homolog, archipelago, Drosophila, Homolog of, CDC4, DKFZp686F23254, F-box and WD Repeat Domain containing 7, F-box and WD-40 Domain Protein 7 (archipelago Homolog, Drosophila), F-box and WD-40 Domain-containing Protein 7, F-box Protein FBW7, F-box Protein FBX30, F-box Protein SEL-10, F-box/WD Repeat-containing Protein 7, FBW6, FBW7, FBX30, FBXO30, FBXW6, FBXW7, FLJ16457, HAgo, hCdc4, Homolog of C elegans sel-10, SEL-10, SEL10)

Size

£731.00

SKU:: 254039
Purity:: Purified by Protein A affinity chromatography.
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Mouse
Immunogen:: Synthetic peptide of human sequence
Clone:: FBOX 3a9/1
Format:: Supplied as a liquid in PBS, 0.09% sodium azide.
Extra Details:: F-box/WD repeat-containing protein 7 (Fbxw7), which is also known as cdc4 and SEL-10. The FBW7/Cdc4 F-box protein was first recognized by its ability to bind cyclin E and the SCF (FBW7) is now known to target c-Myc, c-Jun and Notch for degradation in addition to its role in cyclin E proteolysis. FBW7 negatively regulates several key oncoproteins and is a tumor suppressor that is mutated in a wide spectrum of human cancers. Applications: Suitable for use in Immunofluorescence, Flow Cytometry, Western Blot, Immunoprecipitation, Immunohistochemistry, Immunocytochemistry. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Hybridoma: Sp2/0 Ag.14 myeloma cells with spleen cells from Balb/c mice. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.