254032
Emerin (EDMD, EMD, Emery Dreifuss muscular dystrophy, STA)
Size
£731.00
- SKU:
- 254032
- Purity:
- Purified by immunoaffinity chromatography.
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- Host:
- Sheep
- Immunogen:
- Synthetic peptide: MSKSFRRPGT SLVDADDTFH HQVRDDIFSS SEEEGKDRER PIYGRDSAYQ SIAEYRPISN VSRSSLGLSY, corresponding to internal sequence aa114-183 of Rat Emerin, with N terminal proprietary tag. (P50402)
- Format:
- Supplied as a liquid in PBS, 10% gelatin, 0.09% sodium azide.
- Extra Details:
- Stabilizes and promotes the formation of a nuclear actin cortical network. Stimulates actin polymerization in vitro by binding and stabilizing the pointed end of growing filaments. Inhibits beta-catenin activity by preventing its accumulation in the nucleus. Acts by influencing the nuclear accumulation of beta-catenin through a CRM1-dependent export pathway. Links centrosomes to the nuclear envelope via a microtubule association. EMD and BAF are cooperative cofactors of HIV-1 infection. Association of EMD with the viral DNA requires the presence of BAF and viral integrase. The association of viral DNA with chromatin requires the presence of BAF and EMD. Required for proper localization of non-farnesylated prelamin-A/C. Applications: Suitable for use in Immunofluorescence, Western Blot, Immunocytochemistry, Electron Microscopy. Other applications not tested. Recommended Dilutions: Western Blot: 1:1000. Predicted molecular weight: 30kD. Immunocytochemistry/Immunofluorescence: 1:100 Electron Microscopy: 1:50. (Rat) Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Shipping Conditions:
- Blue Ice