IL-33 (Biotin)

Size

£550.00

SKU:: 228213
Purity:: Purified
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Mouse
Immunogen:: Recombinant protein corresponding to human IL-33.
Clone:: SB127j
Format:: Supplied as a liquid in PBS, sodium azide. Labeled with Biotin.
Extra Details:: Interleukin-33 (IL-33), also known as NF-HEV, is a 30kD protein and a recently identified member of the IL-1 family. This pro-inflammatory cytokine is produced by a variety of cells, but is primarily expressed by endothelial and smooth muscle cells in the vasculature and airways.1 IL-33 binds to the ST2 receptor on target cells which results in the activation of multiple signaling pathways including NF-κB and MAP kinases. Studies have shown that IL-33 promotes T helper type 2 (Th2) cell-mediated immune responses and upregulates production of Th2 associated cytokines including IL-4, IL-5 and IL-13.2,3 In vivo administration of this cytokine in mice resulted in eosinophilia and splenomegaly, as well as induced severe pathological changes in the lungs, gastrointestinal tract and other mucosal organs.2,4,5. Applications: Suitable for use in ELISA. Other applications not tested. Recommended Dilution: ELISA: 1-5ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Shipping Conditions:: Blue Ice