CD49d (VLA-4, Integrin a4, VLA-4a, ITGA4, IA4)

Size

£288.00

SKU:: 228138
Purity:: Purified
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Mouse
Clone:: 7.2
Format:: Supplied as a liquid in 1ml BBS, pH 8.2. No preservative or amine-containing buffer salts added.
Extra Details:: CD49d, a member of the integrin family of extracellular matrix and cell adhesion molecules, is the integrin a4 chain. CD49d associates noncovalently with CD29, the integrin b1 subunit, to form the a4b1 very late antigen-4 (VLA-4) heterodimer. Integrin a4 can also associate with integrin b7 to form the a4b7 heterodimer. It is expressed on most leukocytes, with the possible exception of neutrophils. VLA-4 mediates leukocyte binding to CD106/VCAM-1, and is involved in the migration of leukocytes from blood to tissue at sites of inflammation. VLA-4 can also provide a costimulatory signal to T cells for activation and proliferation. The a4b7 integrin heterodimer is expressed on a small subpopulation of thymocytes, most lymph node T and B lymphocytes, NK cells and eosinophils. Integrin a4b7 also binds to fibronectin and VCAM-1. Applications: Suitable for use in Flow Cytometry, ELISA, Western Blot, Immunoprecipitation. Other applications not tested. Recommended Dilution: Flow Cytometry: 1ug/10e6 cells Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Shipping Conditions:: Blue Ice