CD169 (Sialoadhesin, Siglec-1)

Size

£626.00

SKU:: 227408
Purity:: Purified by Protein G affinity chromatography.
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Rat
Immunogen:: Stromal (reticular) elements from spleen.
Clone:: MOMA-1
Format:: Supplied as a liquid in PBS, 0.09% sodium azide.
Extra Details:: Recognizes murine CD169 is also known as sialoadhesin or Siglec-1. CD169 is a lectin-like receptor expressed by certain populations of macrophages including marginal zone metallophils of the spleen, subcapsular macrophages of lymph nodes and stromal macrophages in bone marrow (Morris et al. 1991). CD169 is a ~185kD sialic acid binding receptor containing 17 immunoglobulin-like domains (Crocker et al. 1992). Expression of CD169 can be induced on macrophages in culture by a serum factor and further modulated by cytokine exposure (McWilliam et al. 1992). Rat anti mouse CD169, has been used for the in vivo depletion of specific macrophage populations (Kraal et al. 1988). Applications: Suitable for use in Immunofluorescence, Flow Cytometry, and Immunohistochemistry. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.