227379
Mistletoe Lectin
Size
£305.00
- SKU:
- 227379
- Purity:
- Purified by thiophilic affinity chromatography.
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- Host:
- Mouse
- Immunogen:
- Recombinant protein corresponding to mistletoe lectin.
- Clone:
- 2A11
- Format:
- Supplied as a lyophilized powder in PBS, pH 7.4. Reconstitute with sterile ddH2O to a concentration of 1mg/ml.
- Extra Details:
- Mistletoe, a semiparasitic plant, holds interest as a potential anticancer agent because extracts derived from it have been shown to kill cancer cells in vitro [1-10] and to stimulate immune system cells both in vitro and in vivo .[10-24] Two components of mistletoe, namely viscotoxins, polysaccharides and lectins, may be responsible for these effects.[10-13,17-19,21-23,25-32] Viscotoxins are small proteins that exhibit cell-killing activity and possible immune-system-stimulating activity.[1,6,18,19,33,34] Lectins are complex molecules made of both protein and carbohydrates that are capable of binding to the outside of cells (e.g., immune system cells) and inducing biochemical changes in them.[10,35-38] In view of mistletoe’s ability to stimulate the immune system, it has been classified as a type of biological response modifier.[35] Biological response modifiers constitute a diverse group of biological molecules that have been used individually, or in combination with other agents, to treat cancer or to lessen the side effects of anticancer drugs. Mistletoe extracts have been demonstrated in preclinical settings to have other mechanisms of action, such as antiangiogenesis.[39] Applications: Suitable for use in ELISA. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months after receipt at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
- Shipping Conditions:
- Blue Ice