Verruculogen (NA 209A, TR 1)

Size

£372.00

SKU:: 226788
Molecular Weight:: 511.6
Purity:: ≥98% (HPLC)
Storage Conditions:: -20°C
Supplier:: United States Biological
CAS Number:: 12771-72-1
Format:: Supplied as a white to off-white solid.
Extra Details:: Fumitremorgin-type alkaloid. Tremorgenic neurotoxic mycotoxin. Selective blocker of KCa1.1 (high-conductance Ca2+-activated K+; BK; maxi-K) channels. Decreases GABA levels in CNS. Increases spontaneous glutamate and aspartate release. At toxic doses, increases the number and decreases the affinity of DHP receptors in rat cortex. Cell cycle inhibitor at the M phase. Inhibits calmodulin and PKC activity. Has apoptotic effects on human T lymphocytes. Stimulates the growth of seedling roots of buckwheat. Synonyms: NA 209A; TR 1, (5R,10S,10aR)-1,10,10a,14,14aS,15bS-hexahydro-10,10a-dihydroxy-7-methoxy-2,2-dimethyl-5-(2-methyl-1-propen-1-yl)-5H,12H-3,4-dioxa-5a,11a,15a-triazacyclooct[lm]indeno[5,6-b]fluorene-11,15(2H,13H)-dione CAS Number: 12771-72-1 Source: Aspergillus fumigatus. Molecular Weight: 511.6 Molecular Formula: C27H33N3O7 Identity: Determined by 1H-NMR and MS. Solubility: Soluble in DMSO, 100% ethanol, methanol or dichloromethane. Purity: ≥98% (HPLC) Form: Supplied as a white to off-white solid. Storage and Stability: May be stored at 4°C for short-term only. Long-term storage is recommended at -20°C. Stable for 6 months after receipt. Protect from light when in solution. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

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