NRF2, Recombinant, Human, aa1-605, His-Tag (Nuclear Factor (Erythroid-Derived 2)-Like 2, NFE2L2)

Size

£512.00

SKU:: 218401
Molecular Weight:: 69.9
Purity:: ~85% (SDS-PAGE)
Storage Conditions:: -20°C
Supplier:: United States Biological
Format:: Supplied as a liquid in PBS, pH 7.4, 10% glycerol.
Extra Details:: Nuclear factor (erythroid-derived 2)-like 2, also known as NRF2, is a bZIP transcription factor that heterodimerize with Maf proteins to bind Mare sequences. The NRF proteins also bind the antioxidant response element (ARE) and are implicated in the regulation of detoxification enzymes and the oxidative stress response. NRF2 is widely expressed and is thought to translocate to the nucleus after treatment with xenobiotics and antioxidants, which stimulate its release from its repressor protein, Keap1. Source: Recombinant protein corresponding to aa1-605 from human NRF2, fused to His-tag at N-terminus, expressed in E.coli. Molecular Weight: ~69.9kD (625aa) Applications: Suitable for use in SDS-PAGE. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing.. Store at -20°C. Aliquots are stable for 6 months after receipt at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.