MESDC1, Recombinant, Human, aa1-362, His-Tag (Mesoderm Development Candidate 1)

Size

£512.00

SKU:: 218334
Molecular Weight:: 40.1
Purity:: ≥95% (SDS-PAGE)
Storage Conditions:: -20°C
Supplier:: United States Biological
Format:: Supplied as a liquid in 20mM Tris-HCl, pH 8.0, 0.1M sodium chloride, 1mM DTT, 10% glycerol.
Extra Details:: Mesoderm development candidate 1, also known as MESDC1, belongs to the MESD family. It is a 362aa protein encoded by a gene that maps to human chromosome 15q25.1. MESDC1 acts as a chaperone for low-density lipoprotein receptor (LDLR) proteins in the ER, and particularly associates with Wnt signaling pathway coreceptors LRP5 and LPR6). MESDC1 is required for proper LRP5/6 folding and maturation to the cell surface, which plays a major role in Wnt signaling. Source: Recombinant protein corresponding to aa1-362 from human MESDC1, fused to His-tag at N-terminus, expressed in E.coli. Molecular Weight: ~40.1kD (385aa), confirmed by MALDI-TOF Applications: Suitable for use in SDS-PAGE. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 6 months after receipt at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.