DYRK1A, Recombinant, Human, aa159-479, His-Tag (Dual-Specificity Tyrosine-(Y)- Phosphorylation Regulated Kinase 1A, Dual Specificity Yak1-Related Kinase, Dyrk, PSK47)

Size

£512.00

SKU:: 218116
Molecular Weight:: 39.4
Purity:: ≥80% (SDS-PAGE)
Storage Conditions:: -20°C
Supplier:: United States Biological
Format:: Supplied as a liquid in 20mM Tris-HCl, pH 8.0, 0.4M urea, 10% glycerol.
Extra Details:: DYRK1A is a member of the dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidin6e repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. Source: Recombinant protein corresponding to aa159-479 from human DYRK1A, fused to His-tag at N-terminus, expressed in E.coli. Molecular Weight: ~39.4kD (343aa) Applications: Suitable for use in SDS-PAGE. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 6 months after receipt at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.