WAY-100635 Maleate (5-HT1A Serotonis Receptor Antagonist, WAY-100635 Maleate, WAY 100635, WAY100635)

Size

£512.00

SKU:: 217874
Molecular Weight:: 538.64
Purity:: ≥97% (HPLC)
Storage Conditions:: 4°C
Supplier:: United States Biological
CAS Number:: 634908-75-1
Format:: Off-white solid
Extra Details:: A selective 5-HT1A receptor antagonist (pKi = 7.9-9.2). WAY-100635 has been reported to have good inhibitory action centrally and peripherally (1mg/kg dose in rats) but has low intrinsic effects, making it a silent 5-HT1A receptor antagonist. WAY-100635 displaced specific binding of the 5-HT1A radioligand, [3H]8-OH-DPAT (8-hydroxy-2-(di-n-propylamino)tetralin), to rat hippocampal membranes with a pIC50 of 8.87. This represented a greater than 100-fold selectivity relative to binding at other 5-HT receptor subtypes and major neurotransmitter receptor, reuptake and ion channel sites. WAY-100635 has been used in a variety of vertebrate species in vivo and in vitro. CAS No: 634908-75-1 Molecular Formula: C25H34N4O2•C4H4O4 Solubility: Water (50mM) Primary Target: 5-HT1A Water Molecules: ≤1mol Storage and Stability: Lyophilized and reconstituted products are stable for 6 months after receipt at 4°C. Reconstitute with sterile ddH2O. Do not freeze. Store at 4°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.