TRPV4 Antagonist I, RN-1734 (2,4-Dichloro-N-isopropyl-N-(2-isopropylaminoethyl)benzenesulfonamide, Transient Receptor Potential Vanilloid-4 Antagonist I, RN1734)

Size

£302.00

SKU:: 217852
Molecular Weight:: 353.3
Purity:: ~95% (HPLC)
Storage Conditions:: -20°C
Supplier:: United States Biological
CAS Number:: 946387-07-1
Format:: Supplied as a yellow solid.
Extra Details:: A cell-permeable benzenesulfonamide compound that selectively antagonizes TRPV4 agonist 4a-PDD-stimulated Ca2+ influx (IC50 = 2.3, 3.2 and 5.9uM, respectively, in HEK293 expressing human, rat, or mouse TRPV4) without affecting the activity of three other human TRP (transient receptor potential) channels, including capsaicin- activated TRPV1, camphor-activated TRPV3, and methanol-activated TRPM8 (IC50 >30uM). Formula: C14H22Cl2N2O2S Molecular Weight: 353.3 Solubility: DMSO (50mg/ml, pale yellow solution) Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile buffer or dH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.