TRPC3 Channel Inhibitor III, Pyr10 (N-(4-(3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl)phenyl)-4-methylbenzenesulfonamide)

Size

£429.00

SKU:: 217850
Molecular Weight:: 449.4
Purity:: ~98% (HPLC)
Storage Conditions:: 4°C
Supplier:: United States Biological
Format:: Supplied as an orange brown semi-solid.
Extra Details:: A cell-permeable pyrazole derivative that acts as a selective blocker of the transient receptor potential cation channel TRPC3-medated ROCE (receptor-operated Ca2+ entry) and inhibits Carbachol-induced Ca2+ entry in TRPC3-expressing HEK293 cells (IC50 = 0.72uM; by Fura-2), while exhibiting much reduced potency against Stim1 and Orai1-coupled CRAC (Ca2+ release-activated Ca2+) channel-mediated SOCE (store-operated Ca2+ entry) in RBL-2H3 cells (IC50 = 13.08uM; by Fura-2). A great complement to Pyr2, Pyr 3, and Pyr6 in Ca2+ signaling studies. Primary Target: TRPC3 Primary Target IC50: 720nM Molar Mass: 449.4 Solubility: DMSO Storage and Stability: May be stored at 4°C. For long-term storage, aliquot and store at 4°C. Do not freeze. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.