Topoisomerase II Inhibitor (BNS-22)

Size

£512.00

SKU:: 217844
Molecular Weight:: 407.46
Storage Conditions:: 4°C
Supplier:: United States Biological
Extra Details:: A potent, 2H-chromen-2-one small molecule inhibitor that is selective for TOP2 (IC50=2.8uM and 0.42uM for TOP2a and TOP2b, respectively). Unlike TOP2 poisons such as etoposide, it does not lead to DNA damage associated with DNA Double-Strand Breaks, as evidenced by the lack of y-H2AX accumulation but instead inhibits kinetoplast DNA decatenation in vitro. This compound affects cell cycle at the M phase and disturbs mitotic spindle formation in HeLa cells at 3-10uM. It also exhibits significant anti-proliferative activities against several human cancer cell lines. Molecular Formula: C24H25NO5 Molecular Weight: 407.46 Purity (HPLC): ≥98% Appearance: White solid Solubility: DMSO Method of Determining Identity: NMR and LCMS Spectometry Storage and Stability: May be stored at 4°C. For long-term storage, aliquot and store at 4°C. Do not freeze. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.