TLR3/dsRNA Complex Inhibitor (CU CPT 4a, Toll-Like Receptor 3/Double Strand RNA Complex Inhibitor)

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£512.00

SKU:: 217837
Molecular Weight:: 377.8
Storage Conditions:: -20°C
Supplier:: United States Biological
CAS Number:: 1279713-77-7
Extra Details:: A thiophenecarboxamidopropionate compound that acts as a direct, competitive and high affinity inhibitor of dsRNA binding to TLR3 (Ki=2.96uM; =19nM for dsRNA binding to TLR3) and selectively antagonizes stimulated TLR3 signaling without affecting TLR1/2, TLR2/6, TLR4 and TLR7 pathways. Shown to efficiently repress TNF-a and IL-1b (IC90=27uM) and NO production (IC50=3.44uM) in Poly(I:C)-induced RAW 264.7 macrophages. Exhibits minimal cytotoxicity (IC50>100uM in RAW 264.7 cells) and is weakly active against a panel of 12-representative kinases and 4-cytochrome enzymes (in vitro assays). Synonyms: (R)-2-(3-Chloro-6-fluorobenzo[b]thiophene-2-carboxamido)-3-phenylpropanoic Acid; CU CPT 4a CAS No: 1279713-77-7 Molecular Formula: C18H13ClFNO3S Molecular Weight: 377.8 Purity: ≥99% (HPLC) Appearance: White solid Solubility: DMSO (50mg/ml) Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months after reciept. Reconstitute with DMSO. Once dissolved, dilute in dH2O or PBS. Store at 4°C. Stable for 6 months after reconstitution. Protect from light.