TLR1/TLR2 Antagonist, CU-CPT22 (Hexyl-3,4,6-trihydroxy-2-methoxy-5-oxo-5H-benzo[7]annulene-8-carboxylate)

Size

£386.00

SKU:: 217836
Molecular Weight:: 362.4
Purity:: ≥98% (HPLC)
Storage Conditions:: 4°C
Supplier:: United States Biological
Format:: Supplied as an orange solid.
Extra Details:: A cell-permeable benzotropolone compound that competes against Pam3CSK4- for TLR1/TLR2 heterodimer binding (Ki = 410nM) and selectively antagonizes against Pam3CSK4-induced RAW264.7 cellular NO production (IC50 = 580nM) without apparent cytotoxicity (up to 100uM and 24h). Exhibits no antagonist activity toward TLR2/TLR6, TLR3, TLR4, TLR7 at 0.5uM and little inhibitory potency against a panel of 10 kinases at 5uM (by <11% inhibition). Molecular Formula: C₁₉H₂₂O₇ Solubility: DMSO Primary Target: TLR1 Molar Mass: 362.4 Storage and Stability: May be stored at 4°C. For long-term storage, aliquot and store at 4°C. Do not freeze. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.