Threonine Dehydrogenase Inhibitor, QC1 (N-Benzyl-4-oxo-2-thioxo-3-(3-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydroquinazoline-7-carboxamide)

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£415.00

SKU:: 217832
Molecular Weight:: 455.5
Purity:: ≥96% (HPLC)
Storage Conditions:: 4°C
Supplier:: United States Biological
CAS Number:: 403718-45-6
Format:: Supplied as a white powder.
Extra Details:: A cell-permeable quinazolinecarboxamide (QC) compound that acts as a potent, reversible and mixed noncompetitive inhibitor of threonine dehydrogenase activity (IC50 ~ 0.5uM for mTDH) with excellent selectivity over hydroxysteroid, alcohol, lactate, or glucose-6-phosphate dehydrogenases (IC50 >10uM). Shown to block threonine catabolism, induce autophagy and impede the growth of highly proliferating mouse embryonic stem cells (mESCs; EC50 ~3uM) with no effect on ESCs-derived embryoid body cells, 3T3 fibroblasts or tumor cells (EC50 ~1 mM). Synonyms: N-Benzyl-4-oxo-2-thioxo-3-(3-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydroquinazoline-7-carboxamide CAS Number: 403718-45-6 Formula: C₂₃H₁₆F₃N₃O₂S Solubility: DMSO Molar Mass: 455.5 Purity: ≥96% (HPLC) Form: Supplied as a white powder. Storage and Stability: Store at -20°C under inert atmosphere. Protect from light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.