Syk Inhibitor V (S-2-(2-((3,5-dimethylphenyl)amino)pyrimidin-4-yl)-N-(1-hydroxypropan-2-yl)-4-methylthiazole-5-carboxamide, Spleen Tyrosine Kinase Inhibitor)

Size

£499.00

SKU:: 217819
Molecular Weight:: 397.5
Purity:: ≥99% (HPLC)
Storage Conditions:: -20°C
Supplier:: United States Biological
Format:: Supplied as a yellow solid.
Extra Details:: A cell-permeable, 4-thiazolyl-2-phenylaminopyrimidine compound that acts as a potent, reversible, and ATP-competitive inhibitor of spleen tyrosine kinase (Syk) (Ki=9nM). Exhibits excellent selectivity over Cdk2 (Ki=3.33uM), ROCK (Ki=2.3uM), Src (Ki=3.33uM), and ZAP70 (Ki=240nM). Shown to inhibit mast cell degranulation (IC50=70nM) that is commonly observed in asthma and other allergic diseases. Synonyms: (S)-2-(2-((3,5-dimethylphenyl)amino)pyrimidin-4-yl)-N-(1-hydroxypropan-2-yl)-4-methylthiazole-5-carboxamide, Spleen Tyrosine Kinase Inhibitor Molecular Formula: C₂₀H₂₃N₅O₂S Molecular Weight: 397.5 Solubility: DMSO (50mg/ml, pale yellow solution) Storage and Stability: Store at -20°C under inert atmosphere. For maximum recovery of product, centrifuge the original vial prior to removing the cap.