Survivin Inhibitor, YM155 (Survivin Inhibitor I, Interleukin Enhancer-Binding Factor 3 Inhibitor)

Size

£358.00

SKU:: 217818
Molecular Weight:: 443.3
Purity:: ~97% (HPLC)
Storage Conditions:: -20°C
Supplier:: United States Biological
CAS Number:: 781661-94-7
Format:: Supplied as a yellow solid.
Extra Details:: A cell-permeable imidazolium derivative that suppresses survivin expression, blocks survivin promoter activity, and induces apoptosis in a variety of tumor cell lines (IC50 = 540nM) in a dose-dependent manner. The main target of YM155 appears to be the interleukin enhancer-binding factor 3 (ILF3/NF110) with shorter C-terminal lengths associated with reduced binding. Exhibits potent anti-tumor effects without any severe systemic toxicity in murine models. Reported to induce tumor regression by suppressing intratumor survivin levels in PC3-xenograph tumor models (by 47% and 80% at 1 and 5mg/kg, respectively. Primary Target: Interleukin enhancer-binding factor 3 (ILF3/NF110) Primary Target IC50: 540nM Secondary Target: Unknown Molar Mass: 443.3 Solubility: DMSO Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months after receipt at -20°C. Reconstitute with sterile buffer or ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.