STAT3 Inhibitor XVI (IL-6 Inhibitor)

Size

£483.00

SKU:: 217813
Molecular Weight:: 446.08
Purity:: ≥98% (HPLC)
Storage Conditions:: -20°C
Supplier:: United States Biological
Format:: Supplied as a gray solid.
Extra Details:: A cell-permeable, arylsulphonamidyl thiophene amide that is shown to reduce IL-6-induced STAT3 transcriptional activity (EC50=15uM) in a luciferase reporter assay, in HeLa cells. It selectively inhibits STAT3, but not STAT1, phosphorylation following IL-6 stimulation in both HeLa and MDA-MB-231 breast cancer cells at concentrations of 10-30uM and 30-100uM, respectively. Following IL-6 stimulation, it suppresses the cell viability of STAT3-dependent cancer cells by 40% compared with that of STAT3-null cancer cells at the low micromolar level. Formula: C21H22N2O3S3 Molecular Weight: 446.08 Solubility: DMSO (50mg/ml, light pink-purple solution) Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile buffer or dH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.