Sphingosine Kinase 1 Inhibitor, SKI-178 (N'-(1E)-1-(3,4-Dimethoxyphenyl)ethylidene)-3-(4-methoxyphenyl)-1H-pyrazole-5-carbohydrazide, Dimethoxyphenyl-ethylidene-methoxyphenyl-pyrazole-carbohydrazide)

Size

£358.00

SKU:: 217804
Molecular Weight:: 394.4
Purity:: ≥92% (HPLC)
Storage Conditions:: 4°C
Supplier:: United States Biological
Format:: Supplied as an off-white powder.
Extra Details:: A cell-permeable pyrazolocarbohydrazide compound that acts as a potent, reversible, sphingosine competitive and ATP-non-competitive inhibitor of sphingosine kinase 1 (SphK1) activity with excellent selectivity over SphK2 (Ki = 1.33 and >> 25uM, respectively). Shown to suppress sphingosine-1-phosphate (S1P) production in A549 cells and efficiently induce apoptosis in several tumor cells (IC50 in the range of 0.1-1.8uM). Synonyms: Dimethoxyphenyl-ethylidene-methoxyphenyl-pyrazole-carbohydrazide, Nʹ-(1E)-1-(3,4-Dimethoxyphenyl)ethylidene)-3-(4-methoxyphenyl)-1H-pyrazole-5-carbohydrazide Molecular Formula: C₂₁H₂₂N₄O₄ Solubility: DMSO Molar Mass: 394.4 Storage and Stability: Store at 4°C under inert atmosphere. For maximum recovery of product, centrifuge the original vial prior to removing the cap.