SOD1 Inhibitor, LCS-1 (4,5-dichloro-2-(3-methylphenyl)-3(2H)-pyridazinone, 4,5-dichloro-2-m-tolylpyridazin-3(2H)-one, Superoxide Dismutase 1 Inhibitor, Lung Cancer Screen 1)

Size

£380.00

SKU:: 217802
Purity:: ≥99% (HPLC)
Storage Conditions:: -20°C
Supplier:: United States Biological
CAS Number:: 41931-13-9
Format:: Supplied as a white solid.
Extra Details:: A 2-phenylpyridazin-3(2H)-one based non-copper chelater that selectively inhibits the activity of Superoxide dismutase 1 (Cu/Zn-SOD) (IC50=1.07uM). Cells over-expressing SOD1 show reduced sensitivity to LCS-1. Shown to preferably inhibit the growth of a variety of human lung adenocarinoma cell lines with EGFR and KRAS mutations (IC50=200nM). Prevents serum-induced activation of the ERK and PI 3-kinase/AKT signaling thereby affecting cell growth and survival. Apparent half-life of this compound is reported to be 6.6min in human liver microsomes. Synonyms: Lung cancer screen 1, 4,5-dichloro-2-m-tolylpyridazin-3(2H)-one, 4,5-dichloro-2-(3-methylphenyl)-3(2H)-pyridazinone, Superoxide dismutase 1 inhibitor CAS Number: 41931-13-9 Formula: C₁₁H₈Cl₂N₂O Solubility: DMSO (50mg/ml, clear, colorless solution) Purity: ≥99% (HPLC) Form: Supplied as a white solid. Storage and Stability: May be stored at 4°C for short-term only. Long-term storage is recommended at -20°C. Stable for 1 year after receipt. Protect from light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.