SN50, NF-kB Cell-Permeable Inhibitor Peptide (AAVALLPAVLLALLAPVQRKRQKLMP)

Size

£607.00

SKU:: 217798
Molecular Weight:: 2781.5
Purity:: ≥97% (HPLC)
Storage Conditions:: -20°C
Supplier:: United States Biological
Format:: Supplied as a lyophilized powder in trifluoroacetate salt.
Extra Details:: Contains the nuclear localization sequence (NLS) of the transcription factor NF-kB p50 linked to the hydrophobic region (h-region) of the signal peptide of Kaposi fibroblast growth factor (K-FGF). The N-terminal K-FGF h-region confers cell-permeability, while the NLS (360-369) inhibits translocation of the NF-kB active complex into the nucleus. In murine endothelial LE-II cells induced by LPS, NF-kB nuclear translocation is maximally inhibited at 18uM. Molecular Formula: C₁₂₉H₂₃₀N₃₆O₂₉S Sequence: H-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Val-Gln-Arg-Lys-Arg-Gln-Lys-Leu-Met-Pro-OH Solubility: H2O (5mg/ml) Molecular Weight: 2781.5 Purity: ≥97% (HPLC) Form: Supplied as a lyophilized powder in trifluoroacetate salt. Storage and Stability: Lyophilized and reconstituted products are stable for 6 months after receipt at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.