217797
SAG Dihydrochloride, Water Soluble (Smoothened Agonist)
Size
£294.00
- SKU:
- 217797
- Molecular Weight:
- 599
- Storage Conditions:
- 4°C
- Supplier:
- United States Biological
- CAS Number:
- 364590-63-6
- Extra Details:
- A cell-permeable benzothiophene compound that modulates the coupling of Smo with its downstream effector by interacting with the Smo heptahelical domain (=59nM). Shown to induce Smo internalization. Shown to induce Hedgehog pathway activation (EC50= ∼3nM in NIH 3T3-derived Shh-LIGHT2 cells) and counteracts Cyclopamine-KAAD inhibition of Smo. Reported to act as an activator at low concentrations and as an inhibitor at very high concentrations. Synonyms: N-Methyl-Nʹ-(3-pyridinylbenzyl)-Nʹ-(3-chlorobenzo[b]thiophene-2-carbonyl)-1,4-diaminocyclohexane, SAG1.3 CAS No: 364590-63-6 Molecular Formula: C₂₈H₂₈ClN₃OS • 2HCl • 2H₂O Molecular Weight: 599 Purity: ≥98% (HPLC) Appearance: White to yellow solid Solubility: Water; DMSO: 10mg/ml NMR: Conforms to structure Mass Spectrophotometry: Conforms to structure Elemental Analysis: As Reported Storage and Stability: May be stored at 4°C. Stable for 6 months after receipt. Reconstitute with DMSO or H2O. Aliquot and store at -20°C.
- Shipping Conditions:
- Blue Ice