Sirtuin-3 Inhibitor, SRT1720 (SIRT3 Inhibitor II, N-(2-(3-(1-Piperazinylmethyl)imidazo[2,1-b]thiazol-6-yl)phenyl)-2-quinolinecarboxamide)

Size

£429.00

SKU:: 217793
Molecular Weight:: 469.6
Purity:: ≥97% (HPLC)
Storage Conditions:: -20°C
Supplier:: United States Biological
CAS Number:: 925434-55-5
Format:: Supplied as a yellow solid.
Extra Details:: A cell-permeable quinolinecarboxamide compound that is shown to inhibit the mitochondrial SIRT3 in a substrate AceCS2-competitive (Ki = 0.56uM; Km = 2.44uM), but NAD+-uncompetitive (Ki = 0.34uM; Km = 280uM), manner. Also reported to decrease cellular p53 Lys382 acetylation (Effective conc. = 10uM in U2OS and MEF cultures) and inhibit p300 HAT activity (IC50 = 9uM) in vitro, as well as offer therapeutic benefits in several murine and rodent type 2 diabetes models (100mg/kg/dayl p.o.) in vivo. Whether and how SRT1720 activates SIRT1 activity remains uncertain. Synonyms: HAT Inhibitor XI, Histone Acetyltransferase Inhibitor XI, p300/CBP Inhibitor IX, SIRT3 Inhibitor II, N-(2-(3-(1-Piperazinylmethyl)imidazo[2,1-b]thiazol-6-yl)phenyl)-2-quinolinecarboxamide, Sirtuin-3 Inhibitor, SRT1720 CAS Number: 925434-55-5 Formula: C₂₅H₂₃N₇OS Molecular Weight: 469.6 Solubility: DMSO (2.5mg/ml, clear, yellow solution) Purity: ≥97% (HPLC) Form: Supplied as a yellow solid. Storage and Stability: May be stored at 4°C for short-term only. Long-term storage is recommended at -20°C. Stable for 1 year after receipt. Protect from light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.