SHIP2 Inhibitor, AS1938909 (3-(2,4-Dichlorobenzyl)oxy]-N-(2,6-difluorobenzyl)thiophene-2-carboxamide, SH2 Domain-containing Inositol 5’-phosphatase 2 (SHIP2) Inhibitor)

Size

£415.00

SKU:: 217790
Molecular Weight:: 371.9
Purity:: ≥95% (HPLC)
Storage Conditions:: 4°C
Supplier:: United States Biological
Format:: Supplied as an off-white solid.
Extra Details:: A cell-permeable thiophenecarboxamide compound that is shown to increase glucose metabolism and activate intracellular insulin signaling. Acts as a potent, competitive and reversible inhibitor of SHIP2 activity (Ki=0.44uM for hSHIP2) with moderate to excellent selectivity over SHIP1 and other related phosphatases (IC50=0.18, 0.57, 21, >50, >50 and >50uM for mSHIP2, hSHIP2, hSHIP1, hPTEN, h-synaptojanin and h-myotubularin, respectively). Elevates insulin-induced pAkt-Ser473 levels and enhances glucose transporter GLUT1 mRNA expression in L6 myotubes. SHIP1 Inhibitor, 3AC is also available. Formula: C₁₉H₁₃Cl₂F₂NO₂S Solubility: DMSO Molecular Weight: 371.9 Storage and Stability: May be stored at 4°C. For long-term storage, aliquot and store at 4°C. Do not freeze. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.