SHIP1 Inhibitor, 3AC (SH2-domain-containing inositol 5’-phosphatase 1 (SHIP1) Inhibitor, 3AC, 3a-Aminocholestane)

Size

£386.00

SKU:: 217788
Molecular Weight:: 387.7
Purity:: ≥95% (NMR)
Storage Conditions:: 4°C
Supplier:: United States Biological
CAS Number:: 2206-20-4
Format:: Supplied as a white solid.
Extra Details:: A cell-permeable steroidal compound that acts as a highly selective SHIP1 activity inhibitor (IC50=10uM) over SHIP2 and PTEN (IC50>1mM in a phosphate release assay). Shown to boost the number of myeloid immunoregulatory cells and circulating granulocytes, and facilitate blood cell recovery in myelosuppressed hosts (60uM, i.p. in mice). Also, promotes apoptosis and reduces SHIP1-expressing KG1 and C1498 cell growth. SHIP2 Inhibitor, AS1938909 is also available. Synonyms: 3α-Aminocholestane, SH2-domain-containing inositol 5ʹ-phosphatase 1 (SHIP1) Inhibitor, 3AC CAS No: 2206-20-4 Molecular Formula: C₂₇H₄₉N Solubility: EtOH Molecular Weight: 387.7 Storage and Stability: May be stored at 4°C. For long-term storage, aliquot and store at 4°C. Do not freeze. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.