SC66, Akt Inhibitor XVIII ((2E,6E)-2,6-bis(4-Pyridylmethylene)cyclohexanone)

Size

£429.00

SKU:: 217784
Molecular Weight:: 276.3
Purity:: ≥95% (HPLC)
Storage Conditions:: -20°C
Supplier:: United States Biological
Format:: Supplied as a pale yellow solid.
Extra Details:: A cell-permeable pyridine compound that selectively targets Akt, but not PLCd, PH domain, preventing Akt membrane localization/activation and rendering Akt in a conformation susceptible to ubiquitination and subsequent proteasomal degradation. Akti-1/2 competes for Akt PH domain binding and blocks SC66-induced Akt ubiquitination and proteasomal degradation. Effectively inhibits HEK293T growth both in vitro (>99 inhibition at 0.4uM) and in mice in vivo (84% of control tumor size with twice weekly i.p. dose of 30mg/kg), Synergizes with LY294002 in cell death induction in HeLa and HS-Sultan cultures in vitro. Molecular Formula: C₁₈H₁₆N₂O Molecular Weight: 276.3 Solubility: DMSO (25mg/ml) Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.