SB-269970 Hydrochloride (5-HT7 Serotonin Receptor Antagonist, SB-269970, SB 26,970, SB 26,970)

Size

£393.00

SKU:: 217782
Purity:: ≥98% (HPLC)
Storage Conditions:: 4°C
Supplier:: United States Biological
CAS Number:: 261901-57-9
Format:: Supplied as an off-white solid.
Extra Details:: A selective 5-HT7 receptor antagonist. Extremely potent in vivo and in vitro. Chronic or acute (even single dose) administration of SB269970 induces functional desensitization of the 5-HT7 receptor system, which precedes changes in the receptor density. This mechanism may be responsible for the rapid antidepressant-like effect of the 5-HT7 antagonist in animal models. SB-269970 is an analogue of SB-258719 and has been shown to have at least 100 fold selectivity versus all other 5-HT receptor subtypes except the human 5-HT5A receptor (pKi values are 8.9, 7.2 and 6.0 for 5-HT7A, 5-HT5A and 5-HT1B). Alternate Names: 5-HT7 Serotonin receptor antagonist, SB-269970, SB 26,970, SB 26,970 CAS Number: 261901-57-9 Form: Supplied as an off-white solid. Purity: ~98% (HPLC) Molecular Formula: C₁₈H₂₈N₂O₃S·HCl Solubility: DMSO Primary Target: 5-HT7 Storage and Stability: May be stored at 4°C. For long-term storage, aliquot and store at 4°C. Do not freeze. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.