SB 399885 Hydrochloride (5-HT6 Receptor Antagonist, SB 399885)

Size

£376.00

SKU:: 217780
Purity:: ~99% (HPLC)
Storage Conditions:: 4°C
Supplier:: United States Biological
CAS Number:: 402713-80-8
Format:: Supplied as a white solid.
Extra Details:: A high affinity 5-HT6 Receptor antagonist (pKi = 9.0). Good solubility (to 100mM in water or DMSO), oral availability, and penetrant to blood brain barrier. Over 200-fold selective for 5-HT6 receptors vs all receptors, ion channels and enzymes tested in Hirst et al. 2006 publication. Shows nootropic, antidepressant and axiolytic effects comparable to well-described drugs such as diazepam, and therefore has been proposed as novel treatment for schizoprenia and Alzheimer’s disease. Solubility: DMSO or H2O Primary Target: 5-HT6 Primary Target Ki: 1nM Storage and Stability: May be stored at 4°C. For long-term storage, aliquot and store at 4°C. Do not freeze. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.