RubR1 Activator, GF-15 (2'-Benzyloxy-2'-demethoxygriseofulvin, (2S,6'R)-(7-Chloro-4,6-dimethoxy-benzofuran-3-on)-2-spiro-1'-(2'-benzyloxy-6'-methylcyclohex-2'-en-4'-one), (2S,5'R)-3'-benzyloxy-7-chloro-4,6-dimethoxy-5'-methyl-spiro(benzofuran-2,4'-cyclohex-2-ene)-1',3-dione, (1'S,6'R)-2'-(benzyloxy)-7-chloro-4,6-dimethoxy-6'-methyl-3H-spiro(benzofuran-2,1'-cyclohex[2]ene)-3,4'-dione, Supernumerary Centrosomes Clustering Inhibitor)

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£594.00

SKU:: 217761
Molecular Weight:: 428.9
Purity:: ≥98% (HPLC)
Storage Conditions:: 4°C
Supplier:: United States Biological
CAS Number:: 888042-13-5
Format:: Supplied as a white solid.
Extra Details:: A cell-permeable 2'-benzyloxy griseofulvin derivative that displays enhanced mammalian cancer-selective toxicity (IC50 ≤2, ≤4, ≤12, and ≥30uM against panels of leukemia, myeloma, solid tumors, and non-malignant cell lines, respectively), but little antifungal activity, by activating spindle-assembly-checkpoint without affecting microtubule kinetochore attachment. Cancer cells are reported to undergo multipolar (MP) mitosis with normal or supernumerary centrosomes in the presence of GF-15, resulting in subsequent apoptotic cell death. Shown to retard HT29 colon cancer & OPM2 myeloma tumor expansion in mice (20mg/kg/day i.p.) in vivo. GF-15 half-life is expected to be least 48h in cultures. Synonyms: Supernumerary Centrosomes Clustering Inhibitor, 2ʹ-Benzyloxy-2ʹ-demethoxygriseofulvin, (2S,6ʹR)-(7-Chloro-4,6-dimethoxy-benzofuran-3-on)-2-spiro-1ʹ-(2ʹ-benzyloxy-6ʹ-methylcyclohex-2ʹ-en-4ʹ-one), (2S,5ʹR)-3ʹ-benzyloxy-7-chloro-4,6-dimethoxy-5ʹ-methyl-spiro(benzofuran-2,4ʹ-cyclohex-2-ene)-1ʹ,3-dione, (1ʹS,6ʹR)-2ʹ-(benzyloxy)-7-chloro-4,6-dimethoxy-6ʹ-methyl-3H-spiro(benzofuran-2,1ʹ-cyclohex[2]ene)-3,4ʹ-dione CAS No: 888042-13-5 Molecular Formula: C₂₃H₂₁ClO₆ Solubility: DMSO Molar Mass: 428.9 Purity: ≥98% (HPLC) Form: Supplied as a white solid. Storage and Stability: May be stored at 4°C for 6 months after receipt.

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