SR2211

Size

£416.00

SKU:: 217753
Molecular Weight:: 527.5
Storage Conditions:: -20°C
Supplier:: United States Biological
CAS Number:: 1359164-11-6
Extra Details:: Retinoic acid receptor-related nuclear receptor γ (RORγ) plays a central role in T cell differentiation, particularly in the differentiation of pro-inflammatory TH17 cells, which are implicated in autoimmune diseases like multiple sclerosis and rheumatoid arthritis.1 SR 2211 selectively binds RORγ (Ki = 105 nM), acting as an inverse agonist of constitutive in vitro RORγ activity (IC50 = 320 nM). It has minimal effects on RORα, LXRα, and FXR activities. SR 2211 significantly inhibits gene expression of IL-17 and IL-23 receptor in activated EL-4 mouse T lymphocytes when given at 5 μM. Synonyms: 1,1,1,3,3,3-Hexafluoro-2-(2-fluoro-4'-((4-(pyridin-4-ylmethyl)piperazin-1-yl)methyl)-[1,1'-biphenyl]-4-yl)propan-2-ol CAS No: 1359164-11-6 Molecular Formula: C₂₆H₂₄F₇N₃O Molecular Weight: 527.5 Solubility: DMF (20mg/ml), DMSO (20mg/ml) and Ethanol (10mg/ml) λmax: 251 nm Purity: ≥98% Appearance: Crystalline solid Storage and Stability: Store at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.