Rho/SRF Pathway Inhibitor, CCG-1423 (N-(2-(4-Chloroanilino)-1-methyl-2-oxoethoxy)-3,5-bis(trifluoromethyl)benzamide)

Size

£415.00

SKU:: 217746
Molecular Weight:: 454.8
Purity:: ≥95% (HPLC)
Storage Conditions:: -20°C
Supplier:: United States Biological
CAS Number:: 285986-88-1
Format:: Supplied as a white solid.
Extra Details:: A cell-permeable benzamide compound that acts as an effective inhibitor against RhoA- and RhoC-mediated cellular activities by targeting signaling events downstream of Ga12/13 and RhoA/C, affecting MKL recruitment and/or postrecruitment function of MKL1, but not SRF-SRE interaction or ROCK kinase activity. CCG-1423 is shown to inhibit RhoC-dependent cell growth in A375M2 and SK-Mel-147 (IC50≤300nM) and block RhoC/ Ga12-mediated PC-13 invasion in Matrigel assays (by ~90% at 3uM). Synonyms: N-(2-(4-Chloroanilino)-1-methyl-2-oxoethoxy)-3,5-bis(trifluoromethyl)benzamide, MICAL-2 Inhibitor I, MRTF-A/SRF Transcription Inhibitor I, MLK1/SRF Transcription Inhibitor I CAS Number: 285986-88-1 Formula: C18H13ClF6N2O3 Solubility: DMSO (10mg/ml) Molecular Weight: 454.8 Storage and Stability: Store at -20°C under inert atmosphere. For maximum recovery of product, centrifuge the original vial prior to removing the cap.