217739
REV-ERB Agonist II, SR9009
Size
£453.00
- SKU:
- 217739
- Molecular Weight:
- 437.9
- Purity:
- ≥96% (HPLC)
- Storage Conditions:
- 4°C
- Supplier:
- United States Biological
- CAS Number:
- 1379686-30-2
- Format:
- Supplied as a dark brown liquid.
- Extra Details:
- A pyrrolidinecarbamate compound that acts as a specific REV-ERB-alpha/beta agonist. Exhibits a direct and reversible binding (Kd = 800nM REV-ERB-alpha) and shows excellent selectivity over a panel of 46 other nuclear receptors. Potently increases REV-ERB-dependent repressor activity (IC50 = 670 and 800nM in Gal4-REV-ERB-alpha and beta transfected HEK 293 cells) and reduces BMAL1 mRNA in HepG2 cells (IC50 = 710nM). Shown to cross the blood-brain barrier and exhibit desirable pharmacokinetic properties. A 7-day administration of SR9009 (100mg/kg, i.p., b.i.d.) causes a significant weight and fat loss in C57BL6 mice with concomitant reduction in plasma glucose and free fatty acid levels, and alters circadian pattern. 217739, CAS # 1379686-30-2, acts as a specific REV-ERB-α/β agonist that exhibits a direct and reversible binding (Kd = 800nM). Synonyms: Ethyl-3-(((4-chlorobenzyl)((5-nitrothiophen-2-yl)methyl)amino)methyl)pyrrolidine-1-carboxylate CAS Number: 1379686-30-2 Molecular Weight: 437.9 Molecular Formula: C₂₀H₂₄ClN₃O₄S Solubility: DMSO Primary Target: REV-ERB-alpha/beta Appearance: Dark brown liquid. Purity: ≥96% (HPLC) Storage and Stability: Store at 4°C under inert atmosphere. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
- Shipping Conditions:
- Blue Ice