RAGE Antagonist, FPS-ZM1

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£326.00

SKU:: 217736
Molecular Weight:: 327.9
Storage Conditions:: -20°C
Supplier:: United States Biological
CAS Number:: 945714-67-0
Extra Details:: A blood-brain-barrier-permeant, non-toxic, tertiary amide compound that acts as a high affinity, potent, multimodal blocker of RAGE (Receptor for Advanced Glycation End products) V domain-mediated ligand binding (Ki = 25, 148, and 230nM, respectively, against Ab40, HMGB1, and S100B, binding to sRAGE). Blocks RAGE-mediated influx of Ab40 and Ab42 into the brain. Also shown to suppress Ab-RAGE induced NF-kB activation and NF-kB-dependent transcription of b-secretase. Daily treatment of APPsw/0 murine AD model (1mg/kg/d via i.p.) is reported to greatly reduce Thioflavin S-positive amyloid plaques in cortex and hippocampus (by 70 to 80%) and restore congnitive performance to the level of non-AD mice. CAS No: 945714-67-0 Synonyms: N-Benzyl-4-chloro-N-cyclohexylbenzamide, Receptor for AGE Antagonist, FPS-ZM1 Molecular Formula: C₂₀H₂₂ClNO Molecular Weight: 327.9 Purity: ≥98% Appearance: White to off-white semi-solid or viscous liquid Solubility: DMF: 30mg/ml; DMF:PBS (pH 7.2); (1:7): 0.12mg/ml; DMSO: 25mg/ml; Ethanol: 15mg/ml Method for Determining Identity: Mass Spectometry Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 6 months at -20°C. Reconstitute with sterile buffer. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Shipping Conditions:: Blue Ice